--- title: Where pre-filled syringe tech transfers go wrong description: "Most products run through development in vials. The move into commercial pre-filled syringe (PFS) manufacturing is where the earlier formulation and device decisions catch up, and where transfer projects lose time.\n\nAnnex 1 has changed what a European sterile fill-finish site has to demonstrate. It is also changing how sponsors evaluate where commercial PFS capacity should sit, at the same time as sterile supply shifts from global sourcing toward regional sourcing.\n\nThis session covers the path from development to commercial PFS supply: when PFS comes into play, where transfer projects encounter difficulty, what it takes to deliver on time and in full, and what Annex 1 means for the European sterile fill-finish landscape." image: https://content.siegfried.ch/hubfs/Siegfried_Hameln_Mai_28-1.jpg --- This is a search field with an auto-suggest feature attached. - There are no suggestions because the search field is empty. - [Careers](https://www.siegfried.ch/careers/) - [Media](https://www.siegfried.ch/media/) - [Investors](https://www.siegfried.ch/investors/) - [Contact us](https://www.siegfried.ch/contact/) [Company](https://www.siegfried.ch/company/) Company [Purpose](https://www.siegfried.ch/company/purpose/) [Strategy](https://www.siegfried.ch/company/strategy/) [Leadership](https://www.siegfried.ch/company/leadership/) [History](https://www.siegfried.ch/company/history/) [Locations](https://www.siegfried.ch/company/locations/) [Offering](https://www.siegfried.ch/offering/) Offering [Drug Substances](https://www.siegfried.ch/offering/drug-substances/) [Exclusive synthesis](https://www.siegfried.ch/offering/drug-substances/exclusive-synthesis/) [API portfolio](https://www.siegfried.ch/offering/drug-substances/api/) [Reference standards](https://www.siegfried.ch/reference-standards/) [Preclinical and early-phase development](https://content.siegfried.ch/siegfried-acceleration-hub) [Alkaloid raw materials extraction](https://extractas.com.au/) [Drug Products](https://www.siegfried.ch/offering/drug-products/) [Oral solid dosage forms](https://www.siegfried.ch/offering/drug-products/oral-solids/) [Sterile injectables](https://www.siegfried.ch/offering/drug-products/sterile-injectables/) [Ophthalmics](https://www.siegfried.ch/offering/drug-products/ophthalmics/) [Inhalation products](https://www.siegfried.ch/offering/drug-products/inhalatives/) [Viral vectors](https://dinamiqs.com/) [Technologies](https://www.siegfried.ch/technologies/) [Sustainability](https://www.siegfried.ch/sustainability/) Sustainability [People](https://www.siegfried.ch/sustainability/people/) [Environment](https://www.siegfried.ch/sustainability/environment/environment/) [Integrity](https://www.siegfried.ch/sustainability/integrity/) [Quality](https://www.siegfried.ch/sustainability/quality/) [Community engagement](https://siegfried.ch/sustainability/community-engagement/) [Risk management](https://www.siegfried.ch/sustainability/risk-management/) [Insights](https://content.siegfried.ch/insights) [![](https://content.siegfried.ch/hubfs/siegfried-logo.svg)](https://www.siegfried.ch/) What are you looking for? 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The move into commercial pre-filled syringe (PFS) manufacturing is where the earlier formulation and device decisions catch up, and where transfer projects lose time. Annex 1 has changed what a European sterile fill-finish site has to demonstrate. It is also changing how sponsors evaluate where commercial PFS capacity should sit, at the same time as sterile supply shifts from global sourcing toward regional sourcing. This session covers the path from development to commercial PFS supply: when PFS comes into play, where transfer projects encounter difficulty, what it takes to deliver on time and in full, and what Annex 1 means for the European sterile fill-finish landscape. Topics Drug Products Pharmaceutical Manufacturing Regulatory support Fill-finish Pre-filled syringes Access the on-demand webinar recording   About the presenter Katrin Solmsdorff + Jens Klein + Thomas Zinn Katrin Solmsdorff is the Head of Project & Program Management at Siegfried’s Hameln site in Germany. She has worked in the pharma industry since 2004, across process validation, technology transfer and project management. Jesn Klein is the echnical Project Manager for PFS at Siegfried, who is building Siegfried’s new PFS filling and visual inspection lines. He spent more than 20 years in production at CDMOs and marketing authorization holders before joining Siegfried. Thomas Zinn serves as the Chief Officer of Aseptic Manufacturing Services at SKAN AG. As pharmaceutical technology engineer, he has served the industry for close to 30 years, working at the interface between development, scale-up and site-to-site transfers.  expect more **Siegfried AG** Untere Brühlstrasse 4 4800 Zofingen, Switzerland [+41 62 746 11 11](tel:+41627461111) [Get in touch](https://www.siegfried.ch/contact-us/) #### About us - [Our company](https://www.siegfried.ch/company/) - [Sustainability](https://www.siegfried.ch/sustainability/) - [Media](https://www.siegfried.ch/media/) - [Investors](https://www.siegfried.ch/investors/) - [Careers](https://www.siegfried.ch/careers/) #### Helpful resources - [Expert insights](https://content.siegfried.ch/insights) - [News archive](https://www.siegfried.ch/news-archive/) - [Reports](https://www.siegfried.ch/investors/investors-download-center-2025/) - [Terms and conditions](https://www.siegfried.ch/terms-and-conditions/) #### Offering - [Drug Substances](https://www.siegfried.ch/offering/drug-substances/) - [Drug Products](https://www.siegfried.ch/offering/drug-products/) - [Technologies](https://www.siegfried.ch/technologies/) 2026 © Siegfried Holding AG - [Privacy Policy](https://www.siegfried.ch/privacy-policy/) - [Legal disclaimer](https://www.siegfried.ch/legal-disclaimer/) - [Imprint](https://www.siegfried.ch/imprint/) ```json { "@context" : "https://schema.org", "@type" : "BlogPosting", "author" : { "@type" : "Person", "name" : "Jens Klein", "url" : "https://content.siegfried.ch/insights/author/jens-klein" }, "dateModified" : "2026-09-28T11:35:47.953Z", "datePublished" : "2026-09-28T11:35:47.000Z", "headline" : "Where pre-filled syringe tech transfers go wrong", "image" : [ "https://content.siegfried.ch/hubfs/Siegfried_Hameln_Mai_28-1.jpg" ], "mainEntityOfPage" : { "@id" : "https://content.siegfried.ch/insights/where-pre-filled-syringe-tech-transfers-go-wrong", "@type" : "WebPage" }, "publisher" : { "@type" : "Organization", "logo" : { "@type" : "ImageObject", "url" : "https://content.siegfried.ch/hubfs/siegfried-logo.svg" } } } ```