Flexible fill-finish services for prefilled syringes and cartridges

From clinical supply to commercial manufacturing, Siegfried supports pharmaceutical and biotech companies with reliable prefilled syringe solutions. Combining proven aseptic manufacturing expertise, advanced fill-finish technologies and dedicated project teams, we help bring innovative therapies to patients with confidence.

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Dedicated teams. Flexible solutions.

Your project is supported by a dedicated team that understands your product and priorities. With an agile, customer-centric approach, we adapt to changing requirements and support your growth from development to commercial supply.

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Proven expertise in sterile injectables

Built on decades of aseptic manufacturing experience, we support both biologics and small molecules with the highest standards of quality, regulatory compliance, and operational reliability.

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Reliable supply. Dual-sourcing flexibility.

With manufacturing capabilities in both Europe and the United States, we help our customers build resilient supply chains through flexible second-source and dual-source strategies.

Advanced PFS manufacturing capabilities

From sensitive biologics to small molecules, our advanced capabilities support product quality, manufacturing flexibility and regulatory compliance. 

Get in touch with our experts

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Protecting sensitive molecules


  • Low-shear filling systems to minimize mechanical harm to complex biologics
  • Temperature control during filling to handle sensitive actives safely
  • Inert atmosphere processing (Argon/N₂) to combat oxygen sensitivity

Ensuring product quality


  • Advanced isolator technology meeting strict FDA hygiene expectations
  • Dual visual inspections incorporating both automated and manual checkpoints
  • 100% in-line weighing, dose and re-dose-in control systems to minimize product loss

Supporting flexible manufacturing


  • Small- and medium-scale batch sizes, with capacities of up to 100,000 units in 48 hours
  • Single-use setups to eliminate cross-contamination risks and speed up changeovers
  • Automated stopper replenishment to drastically minimize human intervention

Regulatory confidence


  • Full Annex 1 compliance and alignment with FDA and EMA requirements, providing security against evolving regulations
  • Strong CMC supply support helping small-to-mid scale companies navigate tech transfers
  • Comprehensive contamination control strategies designed to safeguard product quality and patient safety

Experience across molecules and product types

Biologics
Small molecules
Oncology therapies
Orphan disease products
Temperature-sensitive formulations
Oxygen-sensitive products
Vial-to-PFS transfers

Why partner with Siegfried?

As a trusted partner for sterile injectable manufacturing, Siegfried combines technical expertise, operational flexibility, and a strong commitment to quality. Our dedicated teams work closely with customers to support successful product development, transfer, and commercial supply.

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Dedicated project teams and customer-centric support

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Decades of aseptic manufacturing experience

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Expertise in biologics and small molecules

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Manufacturing capabilities in Europe and the United States

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Strong regulatory and CMC expertise

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Get in touch

Contact us for more information about pre-filled syringes and cartdridges